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Titlebook: Osteoimmunology; Interactions of the Yongwon Choi Conference proceedings 2010 The Editor(s) (if applicable) and The Author(s), under exclu

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Regulation of Osteoblast Differentiation by Runx2, Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking their differentiation into chondrocytes. Runx2 induces the differentiation of multipotent mesench
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Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage,Production of ephrinB2 mRNA and protein are increased by PTH and PTHrP in osteoblasts. Both a synthetic peptide antagonist of ephrinB2/EphB4 receptor interaction and recombinant soluble extracellular domain of EphB4 (sEphB4), which is an antagonist of both forward and reverse EphB4 signaling, were a
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The Unexpected Link Between Osteoclasts and the Immune System,particular, the interaction between immune cells and osteoclasts is a current major topic of critical interest in this field. The macrophage-osteoclast interaction has long been studied, and the T-cellosteoclast interaction also attracted much attention in the study of arthritis. However, recent rep
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NFATc1 in Inflammatory and Musculoskeletal Conditions, particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation. Here, we review how our recently generated NFATc1 conditional knockout mouse has contri
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Novel Functions of RANK(L) Signaling in the Immune System,ly, and have been shown to augment the ability of DCs to stimulate naive T cell proliferation and enhance DC survival. Since another, yet soluble receptor for RANKL, namely OPG, was initially characterized as a factor inhibiting osteoclast development and bone resorption, it was somewhat enigmatic a
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ls of sufficient sophistication to address complex intergene.This textbook explores sustainability, climate change, and the corporate responsibility movement from a broad array of perspectives, including the challenges, risks, and opportunities of ESG policies, energy and environmental science, econ
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