Titlebook: Organtransplantation in Rats and Mice; Microsurgical Techni Wolfgang Timmermann,Heinz-Jochen Gassel,Arnulf Thi Book 1998 Springer-Verlag Be

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https://doi.org/10.1007/978-3-642-72140-3Immunosuppression; bone marrow; liver transplantation; microsurgery; organ; organ transplantation; surgery

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Organ Transplantation in Mice: Current Status and Future Prospectsdeveloped an organ transplant model in rats [2], which made the link between immunology research and clinical transplantation possible. With the development of microsurgery and molecular biology during the 1990s the mouse model for organ transplants has become increasingly popular [3–21]. In the pas

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Guidelines for the Use and Care of Small Laboratory Animals in Transplantation Researchentific but also ethical, legal, and social implications. Although the availability and development of viable alternatives, for example, mathematical models, computer simulation, and in vitro biological systems, are increasing, in many cases live animal research in biosciences currently has no accep

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Technical Aids and Training Program for Microsurgerys been ideal models because of their convenience in handling and the availability of inbred strains. Operations of great complexity can be performed with minimal instrumentation in the rat by the expanded vision provided by surgical microscopes. Therefore the type and quality of the microsurgical in

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Statistical Methods in Small Animal Experimentationocrit can be chosen if it is relevant for the effect of the treatment in question. Usually, an experimenter objects to the choice of just one criterion, arguing that all parameters are equally important. He or she should select one which can be expected to show an effect. For example, in an experime

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Microsurgical Techniques for Vascular Anastomoses: Suture and Cuff Techniqueterations. This chapter describes the techniques of arterial and venous anastomoses which most laboratories presently use for rat organ transplantation. In addition, an alternative technique for vascular anastomosis is described which is especially useful whenever two vessels with different diameter

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Heart Transplantationh some minor modifications such as introduced by Ono and Lindsey in 1969 [2]. Questions on immunology, acute and chronic graft rejection, and their therapy can be very well studied in this model. The operation can easily be carried out with only two vascular anastomoses. This fact plus the quick and

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Techniques of Skin, Renal, and Vascular Transplantation in the RatThe earliest model developed to investigate allograft immune responses in the modern era of transplantation was skin grafting in rabbits [7] which was later applied to rodents [2]. The survival of skin grafts between inbred strains of laboratory animals was utilized by early investigators to define