Titlebook: Organoid Technology for Disease Modelling and Personalized Treatment; Badrul Hisham Yahaya Book 2022 The Editor(s) (if applicable) and The

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Production and Application of Mesenchymal Stem Cell Spheroids for Cartilage and Bone Regeneration,to produce these tissues from stem cells and scaffolds for a long time, combined with some growth factors and inducible factors. However, owing to the complexity of cartilage and bone tissues, these efforts generated limited results. This chapter explores the production and usage of mesenchymal stem

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Genome Editing in Organoid to Improve Understanding of Human Disease,N and TALEN. Although delivering the CRISPR/Cas9 system is still a huge challenge, genome editing is feasible in both cell lines and organoids. The CRISPR/Cas9 system is a useful and effective tool for studying the mechanisms of single-gene or multi-gene diseases and developing genetic models to fin

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Ethical Implications on Organoid,ience, organoid technology poses complex ethical challenges that may hinder future translational benefits for patients. To encourage ethically acceptable innovation for the benefit of patients, the interdisciplinary conversation between diverse stakeholders in organoid research and its translational

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ing, and the American College of Surgeons Committee on Trauma has endorsed this model as a best practice in violence intervention. Guidelines for starting and sustaining these programs are readily available, as is mentorship through the National Network of Hospital-based Violence Intervention Progra

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