Titlebook: Organic Cation Transporters in the Central Nervous System; Lynette C. Daws Book 2021 The Editor(s) (if applicable) and The Author(s), unde

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Organic Cation Transporter Expression and Function in the CNS,ive control over the movement of organic cations and anions into and out of the CNS compartment. In addition, multiple CNS cell types, e.g., astrocytes, ependymal cells, microglia, contribute to processes that maintain the status quo of the CNS milieu. To fulfill their roles, these barriers and cell

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Genetic and Epigenetic Regulation of Organic Cation Transporters,any clinically-relevant drugs such as the antidiabetic agent metformin, the opioid tramadol, and the antimigraine agent sumatriptan. OCT1 (.) and OCT2 (.) are highly expressed in human liver and kidney, respectively, while OCT3 (.) shows a broader tissue distribution. As suggested from studies using

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Organic Cation Transporters in Brain Catecholamine Homeostasis,n. Collectively, catecholamines exert powerful regulation of mood, motivation, arousal, and plasticity. Transporter-mediated uptake determines the peak concentration, duration, and physical spread of released catecholamines, thus playing key roles in determining the magnitude and duration of their m

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The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances,oaminergic equilibrium in the central nervous system. With many psychoactive substances interacting with OCT1-3 and PMAT, a growing literature focuses on characterizing their properties via in vitro and in vivo studies. In vitro studies mainly aim at characterizing compounds as inhibitors or substra

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