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Titlebook: Organic Cation Transporters; Integration of Physi Giuliano Ciarimboli,Sophie Gautron,Eberhard Schlat Book 2016 Springer International Publi

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书目名称Organic Cation Transporters
副标题Integration of Physi
编辑Giuliano Ciarimboli,Sophie Gautron,Eberhard Schlat
视频video
概述Conjugates integrative transporter physiology, with structural and molecular biology, genetics, pharmacology and pathophysiology, offering an integration of the knowledge in these fields.Provides impo
图书封面Titlebook: Organic Cation Transporters; Integration of Physi Giuliano Ciarimboli,Sophie Gautron,Eberhard Schlat Book 2016 Springer International Publi
描述.This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. .This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists..
出版日期Book 2016
关键词Cell Membrane; Cytoplasm; Genetics; Molecular biology; Structural biology
版次1
doihttps://doi.org/10.1007/978-3-319-23793-0
isbn_softcover978-3-319-79534-8
isbn_ebook978-3-319-23793-0
copyrightSpringer International Publishing Switzerland 2016
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Pharmacological and Toxicological Significance of the Organic Cation Transporters OCT and MATE: Druhelia, OCT2 mediates uptake of the drugs such as metformin or cimetidine at basolateral membrane, and MATE1 and MATE2-K mediated the secretion of cationic and zwitterionic drugs at brush-border membrane. In the liver, OCT1 are expressed on the sinusoidal membrane and MATE1 are expressed on the canal
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Genetic Variability in Organic Cation Transporters: Pathophysiological Manifestations and Consequen of plasma and organ concentrations of endogenous molecules and drugs. Hence, genetic variants in the organic cation transporters may confer susceptibility to diseases and may cause variations in drug pharmacokinetics, efficacy and toxicity..This chapter gives a structured overview of the genetic va
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Physiological and Pathophysiological Regulation of Transporters for Organic Cations,oss plasma membranes in a driving force dependent and saturable manner. These transporters are responsible for the cellular uptake and extrusion of many cationic drugs and toxins and therefore prerequisite for their metabolism, therapeutical actions, but also for their negative side effects. Togethe
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