Titlebook: Organelle Contact Sites; From Molecular Mecha Mitsuo Tagaya,Thomas Simmen Book 2017 The Editor(s) (if applicable) and The Author(s), under

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Role of Intra- and Inter-mitochondrial Membrane Contact Sites in Yeast Phospholipid Biogenesis,f the characteristic functions of organelles, recent studies have shown that distinct organelles physically connect and communicate with each other to maintain the integrity of their functions. In yeast, multiple inter- and intramitochondrial membrane contact sites (MCSs) were identified to date and

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Discovery and Roles of ER-Endolysosomal Contact Sites in Disease,h poorly defined, ER-endolysosomal contact sites are quickly becoming recognized as centers for inter-organelle lipid exchange and metabolic decision-making. Here, we review the discovery and current state of knowledge of ER-endolysosomal MCSs with particular focus on the molecular players that esta

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,Mitochondrial-Associated Membranes in Parkinson’s Disease,umber of PD patients due to our expanding life span. Consequently, developing a true disease-modifying therapy is necessary. In this regard, monogenic PD offers a suitable means for determining pathogenesis. Among monogenic forms of PD, mitochondrial dysfunction may be a major cause and is also like

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Role of Endoplasmic Reticulum-Mitochondria Communication in Type 2 Diabetes,th both insulin resistance and β-cell dysfunction in type 2 diabetes mellitus (T2DM), the interplay between these metabolic stresses is less known. Both organelles interact through contact points known as mitochondria-associated membranes (MAM), in order to exchange both lipids and Ca. and regulate

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,Mitochondria–Endoplasmic Reticulum Contact Sites Mediate Innate Immune Responses,gy production, whereas the ER is responsible for folding, transport, and degradation of proteins. In addition to their specific functions, mitochondria and ER actively communicate with each other to promote a variety of cellular events, such as material transfer and signal transduction. Recent studi

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