Titlebook: Organ Regeneration Based on Developmental Biology; Takashi Tsuji Book 2017 Springer Nature Singapore Pte Ltd. 2017 Organ regeneration.Orga

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Early Kidney Specification and Its Recapitulation by Pluripotent Stem Cells,sses. In addition to the technical difficulties of physically examining the early stages of embryogenesis, the unique features surrounding the development of the kidney from three distinct primordia hamper a more complete understanding of the relevant cell fate acquisition mechanisms. We have recent

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Generation of Gastrointestinal Organoids Derived from Human Pluripotent Stem Cells, These studies have been largely driven by developmental biologists who have identified pathways and tissue-specific markers that can be used to direct the differentiation of hPSCs. Furthermore, the identification of Lgr5+ adult stem cells in the mouse small intestine led to the development of proto

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Recapitulating Development to Generate Kidney Organoid Cultures,t of tissues for which this approach to tissue regeneration is becoming feasible. Arguably, the kidney is one of the most complex organs to recapitulate in vitro with the final adult organ containing more than 25 distinct cell types playing a diverse number of distinct functional roles. This organ a

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Development and Bioengineering of Lung Regeneration,rapies. Approaches to meet this need could include either production of stem/progenitor cells for delivery to the damaged native lung to regenerate damaged tissue or engineering of a de novo transplantable organ. In either case, an understanding of normal lung development provides a road map for dir

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Telencephalic Tissue Formation in 3D Stem Cell Culture,eration of telencephalic tissues from human pluripotent stem cells (PSCs) provides a new experimental platform for biomedical research, such as disease modeling, drug screening, and cell-based transplantation therapy.

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Self-Organized Cerebellar Tissue from Human Pluripotent Stem Cells and Its Application to Clinical l (3D) culture system of hPSCs that recapitulates the in vivo microenvironments associated with the isthmic organizer, the source of self-inductive signaling. In this chapter, I explain the cerebellar neurogenesis from hPSCs, focusing on the notion of the positional information and self-formation of