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Titlebook: Organ Preservation; Basic and Applied As D. E. Pegg,I. A. Jacobsen,N. A. Halasz Book 1982 MTP Press Limited 1982 assessment.blood.blood cel

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Energetics and mitochondriable. In part, this was attributed to ‘lack of understanding of the metabolic requirements of the . hypothermic-perfused organ, particularly as it relates to function and pathways that are altered by hypothermia’. The same comments are applicable to liver and heart preservation; indeed these organs c
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Membrane functions their continuing viability. The rationale for such approaches has remained, however, largely empirical, and is based on the principle that if metabolism is responsible for tissue deterioration, and metabolic processes are temperature-dependent, then a reduction in temperature should lead to extende
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Endothelial cell function and organ preservation ,ress of soluble blood components and formed elements of the blood. Excessive leakage of small molecules or of blood cells is prevented, whilst the transport of appropriate nutrients is permitted, as is the emigration of specific classes of white cell from the vessel lumen under certain circumstances
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The dynamics of regional blood flow after ischaemic trauma of the rat kidneyreperfusion after different periods of hypothermic storage using a cold colloidal perfusate it was shown that this increased resistance was more pronounced in the deeper parts of the renal cortex and subsequently in the renal medulla.. This same pattern of regional perfusion was found in recipients
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Kidney blood flow and microcirculatory changes after autologous kidney transplantationemained functionless in a series of 300 renal transplants. Shock in the donor prior to removal of the kidney, prolonged warm ischaemia, and perfusion damage (in addition to rejection) are considered to be probable causes. On the other hand, little is known about the deleterious effect of a fall in b
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