Titlebook: Orexin and Sleep; Molecular, Functiona Takeshi Sakurai,S.R. Pandi-Perumal,Jaime M. Monti Book 2015 Springer International Publishing Switze

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Symptomatic Narcolepsy or Hypersomnia, with and Without Orexin (Hypocretin) Deficiency,y as cases that meet the International Sleep Disorders Narcolepsy Criteria, which are also associated with a significant underlying neurological disorder that accounts for excessive daytime sleepiness (EDS) and temporal associations. By 2005, we have counted 116 symptomatic cases of narcolepsy repor

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Narcolepsy and Idiopathic Hypersomnia,nes (i.e., hypocretin receptor and peptide genes) in animals in 1999 and the subsequent discovery in 2000, of hypocretin ligand deficiency (i.e., loss of hypocretin neurons in the brain) in idiopathic cases of human narcolepsy-cataplexy. The hypocretin deficiency can be clinically detected by cerebr

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A New Class of Hypnotic Compounds for the Treatment of Insomnia: The Dual Orexin Receptor Antagonisor insomnia, including allosteric modulators of the gamma-aminobutyric acid type A receptor (GABAA), such as zolpidem (Ambien.) and eszopiclone (Lunesta.), have undesirable effects that limit their tolerability and utility. The dual orexin receptor antagonists (DORAs), possessing novel mechanisms of

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Pathway and Effect of Intranasal Orexin, of the link between orexin-A deficiency and the disorder narcolepsy, effects of orexin on sleep and wakefulness are of particular interest for clinical purposes. Indeed, the transfer of results of animal studies to study protocols with humans is problematic. The utilized methods used in animals are

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Hypocretin (Orexin) Cell Transplantation as a New Therapeutic Approach in Narcolepsy,bed nocturnal sleep as well as cataplexy. It is known that this disease is caused by deficiency of the neurotransmission system of the peptide named hypocretin (HCRT), also cited as orexin (OX). The ablation of HCRT/OX or HCRT/OX receptors in animal models has supported the understanding of the huma

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