| 书目名称 | Optimizing the "Drug-Like" Properties of Leads in Drug Discovery | | 编辑 | Ronald T. Borchardt,Edward H. Kerns,James L. Steve | | 视频video | | | 概述 | Outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.Emphasis on advancing higher quality drug candidat | | 丛书名称 | Biotechnology: Pharmaceutical Aspects | | 图书封面 |  | | 描述 | Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent years, phar- ceutical companies have come under increasing pressure to introduce new blockbuster drugs into the marketplace more rapidly. Companies have responded to these pressures by introducing new technologies and new strategies to expedite drug discovery and development. Drug discovery and development have traditionally been divided into three separate processes (i. e. , discovery research, preclinical development, and clinical development) that ideally should be integrated both organizationally and functionally. Instead, separate and distinct discovery research, preclinical development, and clinical development divisions were created within many companies during the 1980s and 1990s, Because of their isolation, scientists in the discovery research divisions often were advancing drug candidates into preclinical development that had marginal drug-like properties. For the purpose of thi | | 出版日期 | Book 2006 | | 关键词 | Borchardt; Discovery; Drug; Leads; Like; Optimizing; Properties; lead | | 版次 | 1 | | doi | https://doi.org/10.1007/978-0-387-44961-6 | | isbn_softcover | 978-1-4939-5047-8 | | isbn_ebook | 978-0-387-44961-6 | | copyright | Springer-Verlag New York 2006 |
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发表于 2025-3-21 19:43:27
