Titlebook: Optimizing Pharmacotherapy in Older Patients; An Interdisciplinary Antonio Cherubini,Arduino A. Mangoni,Mirko Petrovi Book 2023 Springer Na

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Prescribing Cascadesen laxatives are prescribed to patients receiving opioid analgesics causing constipation or unintentional and inappropriate as when patients are prescribed diuretics caused by prior prescription of calcium channel blockers causing peripheral oedema, which is misinterpreted as heart failure. Theoreti

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Adherence: How to Measure and Improve Itts of poor adherence to treatment in older patients. Adherence has been defined as the extent to which a person’s behavior—taking medication, following a diet, and/or executing lifestyle changes—corresponds with agreed recommendations from a healthcare provider. When limiting to medication adherence

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Deprescribing: Evidence Base and Implementationence-based prescribing is one of the main reasons for problematic polypharmacy in multimorbid older people, as prescribers try to offer these patients the full list of evidence-based pharmacotherapeutic agents for each individual chronic condition. In addition, many older people attend several physi

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General Principles of Management of Patients with Multimorbidity and Frailtylly described as the coexistence of two or more chronic diseases in the same individual, is a heterogeneous and complex entity characterized by the intricate relationship between chronic conditions and clinical, social, behavioural and functional factors and is associated with worse health outcomes

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Frailty and Drug Therapysons to adverse health outcomes. It serves as a proxy measure of biological age. Evidence detailing the specifics of pharmacotherapy in frail older individuals has been limited. Frailty may modify the effects of drug treatment in older adults and may increase the frequency and intensity of side effe

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Falls and Impaired Mobilityired mobility and use of certain medications (fall risk-increasing drugs, FRIDs). In fact, falls are a common and often overlooked adverse drug event (ADE) in older persons. In this chapter, the evidence regarding FRIDs is being presented as well as the possible mechanisms why FRID use can lead to f

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Optimizing Pharmacotherapy in Older Patients: Deliriumment of delirium; however, it is now accepted that any medication, if administered to individuals at risk, such as those with frailty and/or dementia, can precipitate it. Knowing the potential danger of these medications in terms of delirium development is key, given the impact that delirium exerts