Titlebook: Optimization of Pharmaceutical Processes; Antonios Fytopoulos,Rohit Ramachandran,Panos M. Pa Book 2022 The Editor(s) (if applicable) and T

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Fast Model Predictive Control of Modular Systems for Continuous Manufacturing of Pharmaceuticals,al manufacturing. First-principles models for such modular systems are formulated as partial differential-algebraic equations (PDAEs). The spatial discretization of PDAEs, to enable their numerical solution with standard solvers, usually results in a very high number of states. Quadratic dynamic mat

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Dynamic Modeling and Control of a Continuous Biopharmaceutical Manufacturing Plant,e production of new drugs and therapeutics. In this chapter, a reference plant-wide model for production of a biopharmaceutical compound is proposed. It captures the generic process dynamics of a biopharmaceutical process. As such, it is well-suited to use as a test problem to evaluate different pro

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Model-Based Risk Assessment of mAb Developability,f various antibodies in reducing the risks of fatality or reducing the symptoms of COVID-19, e.g., tocilizumab and sarilumab (Cortegiani et al. .), inevitably increases the importance of the rapid discovery of mAbs and the development of efficient manufacturing processes. Research reports frequently

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Design Framework and Tools for Solid Drug Product Manufacturing Processes,he design flow in the form of an activity model. It highlights the interactions between simulation and experimental investigation, which address the difficulties related to the powder processes, e.g., heterogeneity. The activity model defines two newly developed mechanisms for conducting a simulatio

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Challenges and Solutions in Drug Product Process Development from a Material Science Perspective,the identification of critical process parameters is indeed systematically performed and well understood, but the identification of critical material attributes remains a challenge at various levels. This chapter addresses the challenges associated with material attributes during drug product proces

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Junbo Gong,Zhenguo GaoAnother alternative for developing the system differential equations of motion from scalar quantities is the . where scalars such as the kinetic energy, strain energy, and virtual work are used. In this chapter, the use of . to formulate the dynamic differential equations of motion is discussed. The

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Xiaoxiang Zhu,Lifang Zhou,Richard D. Braatzd continuous systems. As will be shown in later chapters, the concepts introduced and the techniques developed for the analysis of single degree of freedom systems can be generalized to study discrete systems with multi-degree of freedom as well as continuous systems. For this book to serve as an in

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