Titlebook: Opioid Dependence; A Clinical and Epide Heath B. McAnally Book 2018 Springer International Publishing AG 2018 Opioid.Dependence.Abuse.Addic

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Heath B. McAnally MD, MSPHbertragungsflächen statt. Die Zugbelastung nach Abb. 1 bringt maßgebende Beanspruchungen am Lochrande, ferner eine Biegebeanspruchung der Niete gemäß den in Abb. 1 angegebenen Belastungspfeilen. Die Druckbelastung wird gemäß Abb. 2 unmittelbar aus dem Blech auf die Niete übertragen; maßgebend ist hi

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Understanding the Agent, Part I: Opioid Biology and Basic Pharmacologye—whether by quantity or chronicity—both tolerance and adverse effects reduce analgesic efficacy and tip the balance of risk: benefit away from the positive. The body is prepared to some extent to reduce these potential threats by eliminating the agent metabolically. Genetic factors play an increasi

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Best Practices Education, Part I: Pain Physiology, Psychology, and Alternatives to Opioids all, opioids should be part of a comprehensive approach oriented toward prevention/health promotion and including physical and psychological therapies, spiritual support, rational multimodal pharmacotherapy, and if appropriate, procedural or surgical intervention.

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Addressing Host Factors: Primary, Secondary, and Tertiary Prevention of Opioid Dependencening and discontinuation require careful attention to underlying sources of discomfort and distress and to facilitating resilience and self-efficacy. Substitution (e.g., methadone, buprenorphine) and antagonist (e.g., naltrexone) pharmacotherapies in conjunction with psychosocial-spiritual treatment

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