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Development of AAV vectors for the therapy of autoimmune and inflammatory diseases,f payloads twice the packaging capacity. However, a recent clinical trial has put into question the immunogenicity of the AAV capsid in humans suggesting that transduced cells are often targeted by cytotoxic T cells, thus limiting the approaches efficacy .. These advancements and limitations will be

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Three Anthems, a Flag and a Tenor: Introductiongian ‘operetta rev- olution’ speaks of crowds inspired by the martial tones of the opera running into the streets of Brussels while chanting ‘. and opening the fight with the army of the Dutch ruler. Negotiations with the Dutch King commenced a mere three days later. The revolution, so it seems, had