Titlebook: Oncoimmunology; A Practical Guide fo Laurence Zitvogel,Guido Kroemer Book 2018 Springer International Publishing AG 2018 Cancer Immunothera

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Plasmacytoid DC/Regulatory T Cell Interactions at the Center of an Immunosuppressive Network in Brea resistance. In addition, while the immune system is one of the main barriers protecting the body against tumor development, the anti-tumor immune response is compromised in cancer patients. In this chapter we will review the work of the group highlighting the interaction between plasmacytoid DC (pD

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Biology of Myeloid-Derived Suppressor Cellscancer. MDSCs are a heterogeneous population of bone marrow-derived immature myeloid cells that accumulate in the blood, peripheral lymphoid organs, and tumor tissues, which correlates with a poor clinical outcome in cancer patients. The main feature of MDSCs is their ability to suppress antitumor r

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Effect of Pharmaceutical Compounds on Myeloid-Derived Suppressor Cellsrow, in tumor-bearing hosts, MDSCs migrate toward secondary lymphoid organs and the tumor where they contribute to the establishment of an immunosuppressive state. MDSCs directly support tumor growth and metastasis. The elimination of this cell population has been the focus for several years. We her

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Genetics and Immunology: Tumor-Specific Genetic Alterations as a Target for Immune Modulating Therapcer was already discovered in 1863 by Virchow, who hypothesized that sites of chronic inflammation are likely to be the origin of cancer. More recently, immune evasion was announced a hallmark of cancer. In the early phase of tumor induction, the immune system is still able to eliminate most of the

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Peptide-Based Therapeutic Cancer Vaccinesin fragments (peptides) as the antigenic basis for T cell recognition. CD8+ cytotoxic T lymphocytes (Tc) recognize short peptides of 8–11 amino acids in length, presented by MHC class I molecules (HLA class I in human beings), expressed on all nucleated cell types. CD4+ T helper cells (Th) recognize

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