Titlebook: Oncogenes in B-Cell Neoplasia; Workshop at the Nati Michael Potter,Fritz Melchers,Martin Weigert Book 1984 The Editor(s) (if applicable) an

Firefly

https://doi.org/10.1007/978-3-642-69860-6Neoplasia; cell; gene; immunoglobulin; immunology; lymphoma; oncogene

declamation

Introductory Remarks25 years ago (Foulds 1958) Leslie Foulds formulated a number of “rules” for tumor progression, the process whereby “tumors go from bad to worse”, in Peyton Rous’ original description (Rous and Beard 1939). These rules are equally pertinent today and accessible to analysis by the powerful tools of modern biology.

FUME

Tlym-I, a Stage Specific Transforming Gene Shares Homology with MHC I Region GenesWe previously reported the identification of five different stage specific transforming genes activated in T and B-lymphoid neoplasms (Lane, 1982). These genes are evolutionarily We11-conserved between mouse and man and are expressed in multiple neoplasms representative of particular stages of normal lymphoid cellular differentiation.

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Multiple Steps in the Transformation of Normal B Cells Towards NeoplasiaOur current knowledge of the generation, stimulation and half life of normal B cells in the immune system predicts at least three functionally distinct ways for transformation to the neoplastic state.

得意牛

Follicular Hyperplasia in the Prelymphomatous Avian Bursa: Relationship to the Incidence of B-Cell Llymphomas first appear from 8 to 12 weeks after virus infection and eventually metastasize to the spleen, liver and kidneys, resulting in death of the animal (Purchase and Burmester, 1978). The tumor cells are characterized by both cytoplasmic and cell surface immunoglobulin of the IgM isotype (Cooper ..., 1974).

现任者

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Structural and Functional Analysis of ras and Blym Oncogeneslopment of neoplasms originating from a wide variety of differentiated cell types. Since they are detected in only a fraction of individual tumors, however, . gene activation does not appear to be essential for development of any particular type of neoplasm.

珍奇

Disruption and Activation of the c-myb Locus by M-MuLV Insertion in Plasmacytoid Lymphosarcomas Indu leukemia in chickens and transforms myelomonocytic hematopoietic cells in culture (Moscovici 1975). The v-myb sequence is thought to be essential for the oncogenic potential of AMV (Duesberg et al., 1980; Souza 1980a; Gonda et al., 1981) and it appears that only certain target cells are responsive to the v-myb gene product (Moscovici 1975).

Consequence

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