Titlebook: Oncogenes and Tumor Suppressor Genes in Human Malignancies; Christopher C. Benz,Edison T. Liu Book 1993 Kluwer Academic Publishers 1993 DN

雪白

0927-3042 and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging conce

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柔美流畅

nocturia

Nucleoside diphosphate kinases, ,23, and tumor metastasis: Possible biochemical mechanisms,able list of proteases, motility factors, and adhesion molecules for cells and extracellular matrix components have been examined for their potential roles in the tumor metastatic process [reviewed in .,.].

使入迷

Thyroid growth factors and oncogenes,preciable enlarged thyroid glands, however, occur in about 4% of the population in the United States and are more common in areas of endemic goiter [.]. Diffuse and nodular hyperplasia of the thyroid gland with or without hyperfunction (hyperthyroidism) is also a relatively common clinical problem.

elucidate

Transforming growth factor-alpha and its role in neoplastic progression,edia conditioned by a variety of chemically and retrovirally transformed cells, but not by their normal cell counterparts [.–.]. This, in turn, stimulated the belief that the production of SGF contributed to the development and/or maintenance of the transformed phenotype.

招惹

BCL-2: Physiology and role in neoplasia,, .-2, which was originally identified in 1984 [.], appears to function by a mechanism independent of the above two categories, and it may be the first described member of a third broad class of genes whose deregulation plays a role in oncogenesis. It appears to act by inhibiting cell death, rather than by stimulating proliferation.

RAFF

Oncogenes and tumor suppressor genes,essor genes discovered and their complex interactions suggest that the challenge for cancer researchers lies in deciphering the intricate genetic mosaic that characterizes cancer. This chapter will serve as an overview for both types of cancer-associated genes and will include specific examples that highlight important concepts in the field.

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