Titlebook: Oligonucleotide Synthesis; Methods and Applicat Piet Herdewijn Book 2005 Humana Press 2005 DNA.PCR.gene expression.genes.siRNA

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Di- and Oligonucleotide Synthesis Using ,-Phosphonate Chemistry,the preparation of the starting material, nucleoside 3′-.-phosphonate monoesters, their conversion into dinucleoside .-phosphonate diesters, oxidative transformations of dinucleoside .-phosphonates into the corresponding phosphate and phosphorothioate derivatives, and protocols for the synthesis of oligonucleotides and their phosphorothio analogs.

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Base-Modified Oligonucleotides With Increased Duplex Stability, converted into phosphoramidites. The oligonucleotide duplex stability was studied and was compared to that of the parent compounds containing the canonical purine nucleosides. The presence of 7-halogeno or 7-alkynyl substituents increases the duplex stability significantly.

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Chemical Methods for Peptide-Oligonucleotide Conjugate Synthesis,s and their analogs. The first method involves total stepwise solid-phase synthesis on a single support. The second involves preparation of oligonucleotides containing 2′-aldehydes and subsequent chemoselective ligation with functionalized peptides to form hydrazine, oxime, or thiazolidine linkages.

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Douglas J. Dellinger,Jason R. Betley,Tadeusz K. Wyrzykiewicz,Marvin H. Caruthersmehr das, was zum überleben wichtig war, sondern alle begannen sich auf Unterschiedliches zu spezialisieren. Auf das, was andere gebrauchen konnten oder sollten. Koordiniert von Markt oder Staat. Nur so konnte jener bunte Strauß an verschiedenartigsten Berufen zu wachsen beginnen, der zur Signatur d

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