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Titlebook: Oligodeoxynucleotides; Antisense Inhibitors Jack S. Cohen Textbook 1989Latest edition Macmillan Publishers Limited 1989 cancer.cell.DNA.gen

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书目名称Oligodeoxynucleotides
副标题Antisense Inhibitors
编辑Jack S. Cohen
视频video
丛书名称Topics in Molecular and Structural Biology
图书封面Titlebook: Oligodeoxynucleotides; Antisense Inhibitors Jack S. Cohen Textbook 1989Latest edition Macmillan Publishers Limited 1989 cancer.cell.DNA.gen
描述This first-ever book on oligodeoxynucleotides describes in detail the new antisense approach to chemotherapy. It is written by world experts, covers all areas of current knowledge and includes new results. The principle of the antisense approach is that an antisense mRNA base sequence will bind to its target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in understanding gene function, and more specifically as a potential basis for new drugs, notably against cancer and viral genes.
出版日期Textbook 1989Latest edition
关键词cancer; cell; DNA; gene; gene expression; genes; nucleic acid; nucleotide
版次1
doihttps://doi.org/10.1007/978-1-349-10869-5
copyrightMacmillan Publishers Limited 1989
The information of publication is updating

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cently uniform measures reemerged in new results in abstract harmonic analysis. Until now, results about uniform measures have been scattered through many papers written by a number of authors, some unpublished, written using a variety of definitions and notations. Uniform measures are certain funct
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Introduction: Strategies and Realities,m has blossomed to such an extent that it has now reached the stage of popularization (Chase, 1988; Kolata, 1988). But the basis for this approach, and the many assumptions and pitfalls involved in it, cannot be dealt with in a limited popular treatment.
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Synthesis of Oligonucleotides and Oligonucleotide Analogues,e expression. As a consequence, several DNA chemical synthesis methodologies such as the phosphate diester and phosphate triester approaches, which are now primarily only of historical interest, will not be discussed, even though they contributed significantly towards solving many important biologic
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Control of Gene Expression by Oligodeoxynucleotides Covalently Linked to Intercalating Agents and Ning of mRNA precursors; post-transcriptional modifications of mRNAs (capping, polyadenylation); transfer of mRNAs from the nucleus to the cytoplasm; translation of mRNA; mRNA stability …. In most cases this regulation is achieved by proteins that bind to specific regions of DNA or RNA and either blo
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Oligonucleotides Linked to Reactive Groups,of gene expression. Reactive oligonucleotide derivatives represent the affinity reagents capable of bringing about chemical modification of the target nucleic acid residues in the vicinity of the oligonucleotide binding area. In many cases reactive oligonucleotide derivatives are advantageous over t
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Oligonucleotide Recognition of Double-helical DNA by Triple-helix Formation,ing transcription, replication and cell division. The ability to design synthetic molecules that bind sequence-specifically to unique sites on human DNA has major implications for the treatment of genetic, oncogenic and viral diseases. A detailed understanding of the chemical principles for binding
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