Titlebook: Obesity, Diabetes and Inflammation; Molecular Mechanisms Dimiter Avtanski,Leonid Poretsky Book 2023 The Editor(s) (if applicable) and The A

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Advanced Glycation End Products and Diabetes,les. Persistently increased AGEs levels could lead to dysfunction and organ damage via inducing specific signaling and/or directly modifying proteins resulting in the loss of their structure and function. Concerning diabetes and diabetic complications, AGEs are toxic to β-cells and significantly con

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Genetic and Epigenetic Basis of Obesity-Induced Inflammation and Diabetes,tial progress in understanding the biology and genetic contributors to increased body weight, including the links between inflammation, obesity, and type 2 diabetes. However, the exact mechanisms leading to increased food intake and obesity remain unclear, and the cases with identifiable monogenic/M

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Inflammation and Vascular Pathologies,. Inflammatory pathways involving the innate and adaptive immune system mediate the development of atherosclerosis and are potentiated by risk factors such as hyperlipidemia, hypertension, tobacco smoking, and physical activity. Inflammatory markers such as hsCRP and IL-6 may be used to further augm

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Environmental and Lifestyle Factors Influencing Inflammation and Type 2 Diabetes,y and mortality. Environmental factors such as dietary and physical activity play a major role in the pathophysiology of obesity and related complications. Interestingly, the intestinal microbiome emerges as an important environmental factor that should also not be ignored. This chapter explores the

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Inflammation in Pregnant Women with Obesity and Gestational Diabetes Mellitus,isks. This chapter explores the complex metabolic milieu and dynamic adaptive mechanisms of the maternal and placental immune response, the role of inflammation specific to obesity and GDM, and concepts of fetal programming and concludes with clinical and research considerations.

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Potential Pharmaceutical and Non-pharmaceutical Approaches to Obesity and Diabetes: Focus on Inflamure of both obesity and T2D. Studies have shown that a reduction in weight leads to an improvement in inflammation and increased insulin sensitivity. This chapter explores the role of pharmacotherapy and lifestyle interventions in treating obesity and T2D and the impact these therapies have on infla