Titlebook: Non-Neoplastic Hematologic Disorders; A Quick Review of Mo Lubomir Sokol,Ling Zhang Book 2024 The Editor(s) (if applicable) and The Author(

CULP

Benign Histiocytic and Dendritic Cell Disorderse, whereas . is a morphological term that is used to delineate tissue macrophages and sometimes encompasses both macrophages and DCs. Morphologically, we can easily distinguish between DCs (stellate in shape, with numerous cytoplastic projections) and macrophages (large, containing abundant foamy cy

Inveterate

Anemia of Inflammationtypically >8.0 g/dL), which is caused by an underlying inflammatory or autoimmune disease, infection, or neoplasm. AI is the second most prevalent cause of anemia worldwide (after iron-deficiency anemia [IDA]) and is also the most common cause of anemia among hospitalized or chronically ill patients

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背叛者

Sideroblastic Anemiag sideroblasts in bone marrow. Ring sideroblasts are erythroblasts with pathogenic iron-laden mitochondria encircling their nucleus. Morphologically, ring sideroblasts are defined by having a minimum of 5 siderotic granules covering at least one-third of the circumference of the nucleus of erythrobl

Presbyopia

sinoatrial-node

Red Blood Cell Enzymopathiesrocytic hemolytic anemia (NSHA) because of RBC’s decreased ability to manage oxidative stress and/or keep up with metabolic demands. The diagnosis of an RBC enzymopathy usually requires laboratory evidence of a nonimmune (i.e., negative direct antiglobulin test [DAT] or “Coombs test”) hemolytic anem

obnoxious

Red Blood Cell Membrane Disorderso pass through the 3-μm diameter capillaries and the 1-μm to 2-μm-wide endothelial slits in the spleen. Normal RBCs are 7–8 μM in size with a complexly regulated ratio of their membrane surface area to cytoplasmic volume, which gives them the classic biconcave disc shape. The RBC membrane consists o

crease

Congenital Dyserythropoietic Anemiasnical presentation, which typically involves anemia with some degree of hemolysis, ranges in severity and has overlapped with other hereditary hemolytic anemias. Management and prognosis of CDAs, however, do have some differences from other hemolytic anemias; therefore, it is important to consider t

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Cryopathic Hemolytic Anemiasshortened RBC survival. The presence of an autoantibody and/or complement on RBC membranes detected by positive direct antiglobulin test (DAT) is essential for the diagnosis. Most patients with AHA exhibit warm-reactive antibodies usually of the IgG immunoglobulin isotype, whereas the majority of th

Abjure

Lubomir Sokol,Ling ZhangDescribes characteristic clinical features and diagnostic approaches of non-neoplastic hematologic disorders.Contains over 100 Q&A with comments on laboratory values, updated cytogenetic and mutationa