Titlebook: Neuroimmune Diseases; From Cells to the Li Hiroshi Mitoma,Mario Manto Reference work 2024Latest edition Springer Nature Switzerland AG 2024

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Molecular Targeted Therapies in Systemic Autoimmune Diseasess and cell surface molecules such as TNF and IL-6, and small synthetic targeted drugs targeting cellular signalling molecules such as JAKs and other cytokines. These drugs have made it possible to control autoimmune diseases that were considered intractable, for instance, to prevent structural damag

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Postinfectious Immune-Mediated Neurological Diseasesental effect of the immune response to infection. This chapter will cover immune-mediated neurological diseases where infection is the antigenic trigger. Postinfectious cerebellitis, Miller Fisher syndrome, acute disseminated encephalomyelitis, vasculitis and Guillain-Barré syndrome (GBS) are discus

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Paraneoplastic Neurological Syndromesn associated with autoantibodies targeting either intracellular or extracellular neural antigens. Recently, the diagnostic criteria for PNS have been updated in order to highlight the need for a clear causal relationship with cancer to confirm PNS, as well as the relevance of congruent clinical-immu

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Principles in Effector T Cellspressing Th17 cells are essential for disease pathogenesis. Furthermore, CD8. T cells are predominantly observed at human MS lesion sites. However, their functions in this disease remain poorly understood. In this chapter, we summarize the roles of effector T cells in neuroimmune diseases, focusing

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Significance of Autoantibodies, these autoantibodies may be involved in the pathogenesis of the disease by mechanisms such as complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), and modulation of receptor function. The effect of a neuronal autoantibody depends not only on the nature of

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