Titlebook: Nucleoside Analogues; Chemistry, Biology, Richard T. Walker,Erik Clercq,Fritz Eckstein Book 1979 Springer Science+Business Media New York

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Nucleotide Conformations: Rules and Exceptions,d X-ray crystallography- Of these methods, the latter furnishes most details but frequently there is the argument that X-ray experiments are bound to the solid state and the obtained results do not reflect the situation existing in solution. This statement is correct in certain cases but it does not

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Nuclear Magnetic Resonance Studies of Nucleoside Conformational Properties,ems. For this reason, a great deal of research has been devoted in recent years to the conformational analysis of these molecules. Most of the quantitative structural data, i.e., bond lengths, bond angles, interatomic distances, have been derived from X-ray crystallographic measurements in the cryst

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Chemistry of Naturally Occurring Pyrimidine Nucleosides and Analogues,ucleosides are known as minor components. Pyrimidine nucleosides . have been isolated from marine sponges and from microbiological sources. Some of the latter compounds have rather complex structures and exhibit antibiotic properties. The chemistry of pyrimidine nucleosides began at an early point h

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Chemistry of the Heterocyclic Moiety of Purine Nucleosides and Some Closely Related Analogs,urine nucleotides and some closely related analogs. The preformed compounds which are required as the starting materials for the discussion in this specific area are either naturally occurring, provided by fermentation processes or prepared by total synthesis. Since we will be specifically using pre

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Basis for the Selective Antiviral and Antitumor Activity of Pyrimidine Nucleoside Analogs, of course delighted to do so. However, the euphoria soon transferred to despair when I started thinking, and very quickly realized, that we really don’t know the basis for the action of drugs in general, let alone the nucleoside analogs. However, we do know a great deal about the metabolism of nucl

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Development of Antiherpes Virus Agents on the Basis of Virus Induced Enzymes,seases all have substantial toxicity (1,2,3). Recently, several nucleoside analogs such as AraA, 5-alkyl dUrd and Acycloguanine were shown to be effective against herpes simplex virus type 1 infectious diseases without having much toxicity in humans (4–10) however, they all have their own limitation