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Titlebook: Nucleoside Analogues; Chemistry, Biology, Richard T. Walker,Erik Clercq,Fritz Eckstein Book 1979 Springer Science+Business Media New York

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书目名称Nucleoside Analogues
副标题Chemistry, Biology,
编辑Richard T. Walker,Erik Clercq,Fritz Eckstein
视频videohttp://file.papertrans.cn/669/668805/668805.mp4
丛书名称NATO Science Series A:
图书封面Titlebook: Nucleoside Analogues; Chemistry, Biology,  Richard T. Walker,Erik Clercq,Fritz Eckstein Book 1979 Springer Science+Business Media New York
描述This publication contains the Review Lectures given at a joint NATO Advanced Study Institute and a FEB S Advanced Study Course, held at Sogesta (Nr. Urbino), Italy from the 7th - 18th May 1979. The Course entitled "Nucleoside Analogues : Chemistry, Biology and Medical Applications" was held for several reasons. In the past few years, many useful and potentially-useful nucleoside analogues have either reached the stage of clinical use or are undergoing clinical trials. Many more compounds have been synthesised by the organic chemist and little more has been done with them other than possibly a few perfunctory biological tests. This is often due to either a lack of interest or an inadequate knowledge of the testing proced­ ures available or a lack of communication between the chemist, biochemist, pharmacologist and the clinician such that few compounds receive the testing and evaluation which they deserve. The aim of this meeting was to gather together many of the experts in the different scientific disciplines which are involved in the design, synthesis, testing and clinical use of nucleoside analogues, primarily as anti-viral and anti-cancer agents, and to discuss in depth the fund
出版日期Book 1979
关键词Nucleotide; Purine; Pyrimidine; biology; chemistry; enzymes; metabolism; pharmacology; synthesis
版次1
doihttps://doi.org/10.1007/978-1-4615-9137-5
isbn_softcover978-1-4615-9139-9
isbn_ebook978-1-4615-9137-5
copyrightSpringer Science+Business Media New York 1979
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Test Systems for Evaluating the Antitumor Activity of Nucleoside Analogues,ology of the intact tumor-bearing animal in any in vitro system. Tumor cells are mutants of normal cells, coexisting in the same host. Effective cancer chemotherapy may be defined as selective cytotoxicity of anticancer drugs for tumor cells as compared to vital normal cells in the same host such th
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