Titlebook: Nucleic Acids and Molecular Biology; Fritz Eckstein,David M. J. Lilley Book 1989 Springer-Verlag Berlin Heidelberg 1989 DNA.RNA.biology.en

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Nucleic Acids and Molecular Biologyhttp://image.papertrans.cn/n/image/668788.jpg

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978-3-642-83711-1Springer-Verlag Berlin Heidelberg 1989

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The , Repressor from , and Its Action in Regulation-at-a-Distance,Regulation of transcription initiation is a common mechanism for gene regulation both in eukaryotes and prokaryotes. It requires specific binding of regulatory protein(s) to DNA in the vicinity of the target gene. The following characteristics apply to these regulatory proteins in general but repressor proteins are used as examples below:

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DNase Activity of 1,10-Phenanthroline-Copper Ion,ddition to serving as a reliable footprinting reagent, it is useful for defining functionally important sequence-dependent conformational variability of DNA and protein-induced structural changes in DNA.

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Structure of , DNA Polymerase I, Large Fragment, and Its Functional Implications,high-resolution three-dimensional structure has been determined at present (Ollis et al. 1985). Unlike many other replication enzymes, Pol I is active as a single subunit. It is, therefore, one of the simplest known polymerases and has served as a model for the investigation of the molecular details of replication.

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Transcriptional Regulation of Proto-Oncogene c-fos, al. 1966, 1975). It is known to be present as a single copy gene in several species including chicken, mouse and man and the gene product (Fos) is a highly conserved, 380 amino acid, ≈55 kDa nuclear phosphoprotein (Vingron et al. 1988).