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Titlebook: Nucleic Acids and Molecular Biology; Fritz Eckstein,David M. J. Lilley Book 1989 Springer-Verlag Berlin Heidelberg 1989 DNA.RNA.biology.en

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Structural Studies of DNA Through Cleavage by the Hydroxyl Radical,nce) is still an area of active research. The chief experimental difficulty is that DNA as it exists in biological systems is a very large molecule. The traditional methods for chemical structure determination (for example, X-ray crystallography and NMR), while able to provide important insights int
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Structure of , DNA Polymerase I, Large Fragment, and Its Functional Implications,high-resolution three-dimensional structure has been determined at present (Ollis et al. 1985). Unlike many other replication enzymes, Pol I is active as a single subunit. It is, therefore, one of the simplest known polymerases and has served as a model for the investigation of the molecular details
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Mammalian Ribosomal Gene Transcription,f cellular RNA syntheses. This extraordinarily high transcriptional activity reflects the need of the cell to produce more than a million ribosomes per cell cycle. The very efficient and coordinated transcription of these genes ensures the delicately balanced constitution of the protein biosynthesis
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