书目名称 | Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine | 编辑 | Malgorzata Kloc,Jacek Z. Kubiak | 视频video | http://file.papertrans.cn/669/668744/668744.mp4 | 概述 | Examines effects of changes in nuclear, chromosomal and genomic architecture in the cell.Addresses implications of such changes for cell development and maturation.Also covers possible disease-related | 丛书名称 | Results and Problems in Cell Differentiation | 图书封面 |  | 描述 | .This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases..The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems..The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability ofthe genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macrom | 出版日期 | Book 2022 | 关键词 | Cell Nucleus; Chromosomal Architecture; Chromatin Organization; Genomic Architecture; Gene Expression; Nu | 版次 | 1 | doi | https://doi.org/10.1007/978-3-031-06573-6 | isbn_softcover | 978-3-031-06575-0 | isbn_ebook | 978-3-031-06573-6Series ISSN 0080-1844 Series E-ISSN 1861-0412 | issn_series | 0080-1844 | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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