Titlebook: Nuclear Receptors in Human Health and Disease; Moray J. Campbell,Charlotte L. Bevan Book 2022 The Editor(s) (if applicable) and The Author

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Nuclear Receptors in Human Health and Disease978-3-031-11836-4Series ISSN 0065-2598 Series E-ISSN 2214-8019

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0065-2598 tors as drug targets.Invaluable for all stages from undergra.This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overv

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Book 2022e-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the rea

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Corticosteroid Receptors in Cardiac Health and Diseasegy failure in cardiomyocytes leading to mitochondria-initiated cardiomyocyte death (Ingwall and Weiss, Circ Res 95:135–145, 2014; Ingwall , Cardiovasc Res 81:412–419, 2009; Zhou and Tian , J Clin Invest 128:3716–3726, 2018). In contrast, animal studies suggest GR activation in cardiomyocytes has a cardioprotective role, including in heart failure.

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Physiological Convergence and Antagonism Between GR and PPARγ in Inflammation and Metabolism cell types and tissues, including immune cells, adipose tissue and the liver. Understanding the coordinated control of these NR pathways should advance studies in the field and potentially pave the way for developing new therapeutic approaches to exploit the GR:PPARγ crosstalk.

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Circadian Rhythm and Nuclear Receptorsuclear receptor family. An emerging theme is reciprocal regulation of key processes by different members of the nuclear receptor family, for example NR1D1/2, and NR1F1, in regulation of the core circadian clock transcription factor BMAL1.

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