| 书目名称 | Nuclear Receptors in Human Health and Disease |
| 编辑 | Moray J. Campbell,Charlotte L. Bevan |
| 视频video | |
| 概述 | Exposition from field leaders on Nuclear Receptors‘ roles in human development, health and disease.State-of-the-art summary of Nuclear receptors as drug targets.Invaluable for all stages from undergra |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. .Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to |
| 出版日期 | Book 2022 |
| 关键词 | Cancer; Development; Drug design; Epigenomics; Genomics; Metabolism; Reproduction |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-031-11836-4 |
| isbn_softcover | 978-3-031-11838-8 |
| isbn_ebook | 978-3-031-11836-4Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 18:29:18
