| 书目名称 | Nuclear Receptors | | 副标题 | The Art and Science | | 编辑 | Mostafa Z. Badr | | 视频video | | | 概述 | Covers how produced modulators are evaluated experimentally and eventually in relevant disease states, before reaching the phase of developing more efficient and/or less toxic therapies.Explains how s | | 图书封面 |  | | 描述 | Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases..This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through ca | | 出版日期 | Book 2021 | | 关键词 | molecular pharmacology; drug design; PPAR; PXR; metabolic diseases; vitamin d receptor; ligand; target tran | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-78315-0 | | isbn_softcover | 978-3-030-78438-6 | | isbn_ebook | 978-3-030-78315-0 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 18:22:49
