Titlebook: Novel Frontiers in the Production of Compounds for Biomedical Use; Annie Broekhoven,Fred Shapiro,Jozef Anné Book 2002 Springer Science+Bus

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Resistance to aminoglycoside Antibiotics: Function meets structure emergence of resistance in both Gram-positive and Gram-negative organisms. The principle route of resistance to the aminoglycoside antibiotics is through the expression and action of enzymes that covalently modify the compounds, Chemical modification takes the form of phosphorylation, acetylation,

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The Genetics and Biochemistry of Resistance to Glycopeptide Antibioticsnterococci results from new pathways of peptidoglycan biosynthesis together with elimination of peptidoglycan precursors with high affinity for glycopeptides. In staphylococci the main mechanism appears to involve sequestration of the antibiotic in the outer layers of the cell wall before it reaches

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β-Lactamases, an Old but Ever Renascent Problemagents and the major resistance mechanism involves the predominant participation of β-lactamases, enzymes which catalyse very efficiently the hydrolysis of the amide bond in the β-lactam ring. On the basis of their primary structures, these enzymes have been divided into four distinct classes. Enzym

压倒性胜利

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Glycosylation of Antibiotics and Other Agents from Actinomycetese been started to be used as targets for biocombinatorial product design together with various aglycones. Examples of pathways for the activation and biosynthesis of NDP-sugar derivatives and the glycosyltransferases transferring them are reported.

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