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Titlebook: Novel Chemotherapeutic Agents: Preactivation in the Treatment of Cancer and AIDS; Kirpal S. Gulliya Book 1996 Springer-Verlag Berlin Heide

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Photochemistry and Photophysics of Merocyanine 540,radiolysis, in an effort to identify important but highly reactive intermediates. Knowing the nature and fate of these intermediates is of great value for formulating reaction mechanisms and, once the mechanism is known, optimizing the process of interest. A few days spent with such equipment genera
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The Role of Topoisomerases and Apoptosis in the Mechanism of Action of Preactivated Compounds,and merodantoin is provided. The first set of experiments was designed to assess the potential involvement of oxygen derived species in the pMC540 mediated cytotoxicity. The rationale for this approach, at the time, was based on the observations that the in vitro cytotoxicity profile of pMC540 paral
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Modulation of Oncogenes with Preactivated Compounds,ctivation. The studies of the mechanism of action of these compounds have also been summarized. In this concluding chapter, data from ongoing studies related to the effect of preactivated merocyanine 540 (pMC540) on the modulation of selected oncogenes will be discussed.
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Epilogue, on preactivation, even at the risk of being redundant, I would like to summarize the salient points of this technology obtained to date. However, before proceeding with these points, I want to document a recollection of my first pleasant and uplifting experience that occurred soon after the discove
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