Titlebook: Novel Approaches to the Treatment of Alzheimer’s Disease; Edwin M. Meyer,James W. Simpkins,Jyunji Yamamoto Book 1989 Springer Science+Busi

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Muscarinic and Nicotinic Receptors in Alzheimer’s Disease: Rationale for Cholinergic Drug Treatmentntrast to muscarinic receptors, results concerning the fate of neuronal nicotinic receptor populations in AD cortex are more consistent. These studies indicate that the density of nicotinic receptors, at least in cortical structures, is severely reduced in AD (3,5,13,14). It is essential to de­termi

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Approaches to Gene Therapy in the CNS: Intracerebral Grafting of Fibroblasts Genetically Modified toveral advantages over other current methods of gene transfer (2): 1) infection by retrovirus vectors is extremely efficient for a broad range of cell types and species, with up to 100% of the target cells expressing the transgene; 2) the viral genomes have a relatively large capacity for foreign DNA

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