Titlebook: Notch Signaling in Embryology and Cancer; Molecular Biology of Jörg Reichrath,Sandra Reichrath Book 2020Latest edition The Editor(s) (if ap

天然热喷泉

Interaction of Long Noncoding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss,d can be regarded as potential biomarkers and therapeutic targets. Along this chapter, we summarize the cross talk between the Notch signaling pathway and their most important modulating lncRNAs, as well as the pathological consequences of these interactions, in different tissues.

胡言乱语

Book 2020Latest editionummarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Ad

CIS

Ligand-Induced Cis-Inhibition of Notch Signaling: The Role of an Extracellular Region of Serrate,ligands and the receptor. Some of the protein domains involved in trans-activation are also used for cis-inhibition, but some are used uniquely for each process. In this work, the involvement of various ligand regions and the receptor are discussed in relation to their contributions to Notch signaling.

airborne

Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle ctivation. However, a ligand-independent Notch activation has also been described in a few cellular contexts. Here, we focus on one of such contexts, . muscle stem cells, called AMPs, and discuss how insulin-dependent noncanonical activation of Notch pushes quiescent AMPs to proliferation.

farewell

Molecular Regulation of Notch Signaling by Gremlin,ctivated in pathological conditions. Gremlin is emerging as a potential therapeutic target and biomarker of renal diseases. Here we review the role of the Gremlin–VEGFR2 axis in renal damage and downstream signaling mechanisms, such as Notch pathway.

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