Titlebook: Notch Signaling; Methods and Protocol Hugo J. Bellen,Shinya Yamamoto Book 2014 Springer Science+Business Media New York 2014 Notch activity

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Analyzing the Posttranslational Modification Status of Notch Using Mass Spectrometry,D) is modified with .glycosylation and at least three types of .glycosylation (.fucose, .glucose, and .GlcNAc), while the intracellular domain is hydroxylated, phosphorylated, and ubiquitinated. In order to analyze the structure and function of the .glycans decorating the ECD, we have developed semi

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Identifying Direct Notch Transcriptional Targets Using the GSI-Washout Assay,wever these techniques lack the ability to resolve primary and secondary transcriptional events. In contrast, the γ-secretase inhibitor (GSI) washout assay takes advantage of the reversibility of GSI, a pharmacological inhibitor of Notch signaling, along with the ability of cycloheximide to prevent

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1064-3745 key tips on troubleshooting and avoiding known pitfalls..Authoritative and practical,. Notch Signaling: Methods and Protocols. is a valuable contribution to hundreds of labs and thousands of scientists who pursue this research area with vigor. .978-1-4939-5510-7978-1-4939-1139-4Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Introduction to Notch Signaling,al disorders, stroke, and especially cancer. Pharmacological studies are actively pursuing key components of the pathway as drug targets for potential therapy. In this chapter, we will provide a brief historical overview of Notch signaling research and discuss the basic principles of Notch signaling

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Genetic Screens to Identify New Notch Pathway Mutants in ,,long with clonal analysis via FRT-mediated mitotic recombination. These F1 clonal screens allow rapid phenotypic screening within clones of mutant cells induced at specific developmental stages and in tissues of interest, bypassing the pleiotropic effects of isolated mutations. More importantly, sin

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Emiliana Tognon,Thomas Vaccariuents, and bureaus, facilitating their grazing rights and opportunities. There is little incentive to economize on the use of this common resource, since no political actor has to fear being held responsible for the problem. The common pool is a common(s) problem.

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