Titlebook: Nonlinear Excitations in Biomolecules; Les Houches School, M. Peyrard Conference proceedings 1995 Springer-Verlag Berlin Heidelberg 1995 D

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Model simulations of base pair motion in B-DNAiption of a gene begins with the recognition by RNA Polymerase of a segment of DNA called a “promoter site” [1]. Apparently, RNA Polymerase can recognise and bind to these characteristic sequences of about 50 base pairs. This recognition is a dynamical process. The genetic code is statically inscrib

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A nonlinear model for DNA meltingicient if we do not understand how the genome is expressed. One fundamental aspect is the regulation of the expression, in particular how many times a gene is read, or how fast it is expressed. This is a difficult and interdisciplinary, but fascinating problem which will require a cooperation betwee

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Multi-basin dynamics of a protein in aqueous solutionnear excitations, such as intermittency, for various representations of the protein dynamics and structure. The protein backbone dihedral angles show fast correlated transitions from one minimum well to another. Each transition is followed by small overdamped oscillations. Equal-time cross correlati

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Conformational dynamics of proteins: beyond the nanosecond time scale scale. Fast biochemical reactions like the primary steps in photosynthesis last few picoseconds. Most biochemical reactions like enzymatic processes take much longer — microseconds or even few milliseconds. They are often accompanied by larger structural rearrangements in the protein, called confor

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