Titlebook: Nongenotoxic Carcinogenesis; Andrew Cockburn,Lewis Smith Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 DNA.Hormone.br

MONY

Evaluating Carcinogenic Risks,ly related to the way many defend their articles of faith than to the way in which data are evaluated objectively. Nevertheless, in the selection of hazards for evaluation, public opinion will and should be influential.

palpitate

汇总

Nongenotoxic Chemical Carcinogens: Evidence for Multiple Mechanisms,hanisms, such as by generating oxidative products which can damage DNA. This paper will focus on the minimalist definition of mutagenicity and how it may aid in identifying and understanding chemicals which operate through nonmutagenic mechanisms to induce cancer.

牢骚

Nongenotoxic Carcinogenesis in the Liver, is not only a problem in rodents, and assessment of human health risks is urgently required. For this purpose we need to know the relevant .biological effects of these agents in rodent and human liver as well as the mechanisms underlying carcinogenesis.

helper-T-cells

有杂色

The Role of Genotoxic and Nongenotoxic Agents in Multistage Carcinogenesis of Mouse Skin,n attempts to enter a suicide pathway, which is a frequent primary response to DNA-damaging agents. All of this must, of course, take place within the correct target cell, i.e., either a stem cell with a naturally extended lifespan, or a more committed cell which can acquire an extended lifespan upon exposure to a carcinogenic stimulus.

重力

Nongenotoxic Chemical Carcinogens: Evidence for Multiple Mechanisms,For the purpose of this discussion a minimalist definition of a genotoxic carcinogen will be used. This definition includes chemicals which possess one of the structural alerts, generally indicative of electrophilic potential (Miller and Miller 1977) defined by Ashby (1985; Tennant and Ashby 1991),

COW

Oxidative Damage and Carcinogenesis,nts are ubiquitous in our natural environment but they can also be formed in the tissue by endogenous cellular mechanisms (Cerutti 1985; Kozumbo et al. 1985; Cerutti and Trump 1991). Oxidants can introduce structural damage to DNA, leading to chromosomal aberrations and point mutations. Point mutati

foppish

DNA Damage by Free Radicals. Mechanism, Meaning and Measurement,H.O.), and hypochlorous acid (HOC1), the latter being generated by the enzyme myeloperoxidase in neutrophils (for reviews, see di Guiseppi and Fridovich 1984; Halliwell and Gutteridge 1989; Weiss 1989). Exposure of living organism to background levels of ionizing radiation leads to homolytic fission

coalition

,α2μ-Globulin Mediated Male Rat Kidney Carcinogenesis, dogs, and monkeys do not develop this disease when exposed to agents which cause this syndrome in male rats (Borghoff et al. 1990; Alden 1986; Swenberg et al. 1989; Halder et al. 1985). Likewise, there are no data suggesting that these agents cause protein droplet accumulation in the kidneys of hum