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Titlebook: Non-coding RNAs in Colorectal Cancer; Ondrej Slaby,George A. Calin Book 2016 The Editor(s) (if applicable) and The Author(s), under exclus

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发表于 2025-3-21 20:05:18 | 显示全部楼层 |阅读模式
书目名称Non-coding RNAs in Colorectal Cancer
编辑Ondrej Slaby,George A. Calin
视频video
概述First book focused on all classes of non-coding RNAs in colorectal cancer.Essential information about biology and deregulation of non-coding RNAs in colorectal cancer.Involvement of non-coding RNAs in
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Non-coding RNAs in Colorectal Cancer;  Ondrej Slaby,George A. Calin Book 2016 The Editor(s) (if applicable) and The Author(s), under exclus
描述.This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. ..This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. ..The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology. .
出版日期Book 2016
关键词Non-coding RNAs; biomarkers; colorectal cancer; long non-coding RNAs; microRNAs; pathogenesis; therapy
版次1
doihttps://doi.org/10.1007/978-3-319-42059-2
isbn_softcover978-3-319-82491-8
isbn_ebook978-3-319-42059-2Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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发表于 2025-3-21 21:34:31 | 显示全部楼层
Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancerre major challenges in the treatment of CRC. Understanding mechanisms underpinning the pathogenesis is therefore critical in developing novel agents for CRC treatments. A large number of evidence has demonstrated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncR
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MicroRNAs and Inflammation in Colorectal Cancer CRC. The use of anti-inflammatory drugs prevents the development of colorectal cancer..Several molecular mediators are connecting the pathways that are involved in inflammatory conditions and in carcinogenesis. By the way these pathways are tightly interwoven, with the consequence that a deregulati
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Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions st formation. The EMT program is co-opted by epithelial tumor cells and endows them with features necessary for spreading to distant sites, such as invasion, migration, apoptosis resistance and stemness. Thereby, EMT facilitates metastasis formation and therapy resistance. A growing number of transc
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Non-coding RNAs Functioning in Colorectal Cancer Stem Cells the existence of CSCs which, thanks to their self-renewal properties, are able to drive the expansion and the maintenance of malignant cell populations with invasive and metastatic potential in cancer. Increasing evidence showed the ability of such cells to acquire self-renewal, multipotency, angio
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Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectalc mechanisms, such as microRNAs (miRNAs). CRC cases are predominantly sporadic in which the disease develops with no apparent hereditary syndrome. The last decade has seen the progress of genome-wide association studies (GWAS) that allowed the discovery of several genetic regions and variants associ
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Circulating Non-coding RNA as Biomarkers in Colorectal Cancerm. Concentration of circulating (cell-free) microRNAs, and possibly of other non-coding RNAs, could therefore serve as valuable colorectal cancer biomarker and could deliver insight into the disease process. This chapter addresses the recent discoveries on circulating microRNA and long non-coding RN
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