| 书目名称 | Non-Protein Coding RNAs | | 编辑 | Nils G. Walter (Associate Professor of Chemistry), | | 视频video | | | 概述 | Biophysical perspective on a rapidly expanding number of non-protein coding RNAs.Overview on how non-protein coding RNAs work and how biophysical techniques and other probing techniques help delineate | | 丛书名称 | Springer Series in Biophysics | | 图书封面 |  | | 描述 | The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, Andrew Fire and Craig Mello. This prize, which follows “RNA” Nobels for splicing and RNA catalysis, highlights just one class of recently discovered non-protein coding RNAs. Remarkably, non-coding RNAs are thought to outnumber protein coding genes in mammals by perhaps as much as four-fold. In fact, it appears that the complexity of an organism correlates with the fraction of its genome devoted to non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic tra- posons, higher-level organization of eukaryotic chromosomes, and gene expression are found to be largely directed by non-protein coding RNAs. Currently, bioinformatic, high-throughput sequencing, and biochemical approaches are identifying an increasing number of these RNAs. Unfortunately, our ability to characterize the molecular details of these RNAs is significantly lacking. The biophysical study of these RNAs is an emergent field that is unraveling the molecular underpinnings of how RNA fulfills its multitude of roles in sustaining cellular life. | | 出版日期 | Book 2009 | | 关键词 | Einzelmolekülmikroskopie; FRET; Kernspinresonanz; Nuclear Magnetic Resonance; Riboswitch RNA; Röntgenstru | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-70840-7 | | isbn_softcover | 978-3-642-08980-0 | | isbn_ebook | 978-3-540-70840-7Series ISSN 0932-2353 Series E-ISSN 1868-2561 | | issn_series | 0932-2353 | | copyright | Springer-Verlag Berlin Heidelberg 2009 |
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发表于 2025-3-21 16:27:56
