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Titlebook: Non-Opioid Analgesics in the Treatment of Acute Pain; Johannesbergs Slott, M. J. Parnham Conference proceedings 1997 Springer Basel AG 1997

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Routines, practice and needs for analgesics in out-patient surgery in Sweden, to maintain alertness, ambulation, analgesia and alimentation. In a recent national survey of over 1000 patients it was found that 64% of post-operative patients interviewed had mild pain, 25% moderate pain and 11% severe pain (mainly after inguinal hernia, skeletal surgery or breast surgery) on re
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Conference proceedings 1997ime over the last 75 years in many clinical settings throughout the world. Some 20 years ago, however, concern arose over the implications of isolat­ ed reports of agranulocytosis following use of dipyrone. Based on these initial cases the Swedish authorities ordered the withdrawal of the drug from
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Non-opioid analgesics in the treatment of acute pain,s directly related to their mechanism of action. An average of 50– 60% of patients suffer from nausea or vomiting with opioids. Respiratory depression can be reduced with patient-controlled analgesia, though it always remains a risk. Local anaesthetics must also be administered by skilled physicians, but are very useful for post-operative pain.
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978-3-7643-5680-4Springer Basel AG 1997
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Clinical pharmacokinetics of dipyrone and its metabolites,ipyrine (MAA), following oral administration. Recent studies have shown that oral bioavailability of dipyrone tablets is 85%. Maximal plasma concentrations of MAA after oral dipyrone (0.75 g –1.5 g) are achieved in 1–1.5 h and these kinetics are little affected by food.
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