Titlebook: Nitroarenes; Occurrence, Metaboli Paul C. Howard,Stephen S. Hecht,Frederick A. Belan Book 1990 Springer Science+Business Media New York 199

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Carcinogenicity of Dinitroarenes in Rat Lungete combustion of fossile fuel; these compounds are mostly coexistent with mononitroarenes in particles from diesel emission, kerosene heater and city gas emission, and airborne pollutants (see review by Tokiwa and Ohnishi, 1986).

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In Vivo Metabolism and Genotoxic Effects of the Air Pollutant and Marker for Nitro-Pah’s, 2-Nitroflu with the formation of nitro-PAH’s as a result, a reaction which is catalyzed by a low pH. 2-Nitrofluorene (NF), a marker for nitro-PAH, is in vivo metabolized via two different routes. After inhalation there is a formation of potent mutagenic metabolites, ON-NF’s, which are distributed in the body.

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Nitroarenes: Their Detection, Mutagenicity and Occurrence in the Environmentchemical analysis. Studies of the extractable organic matter associated with airborne particles show that substantial mutagenicity is associated with fractions which are more polar than the polycyclic aromatic hydrocarbons (PAH). These mutagenic polar neutral and acidic fractions contain nitroarenes

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The Atmospheric Formation of Nitroarenes and Their Occurrence in Ambient Air polycyclic aromatic hydrocarbons (РАН) and their nitro-derivatives, as well as on the ambient concentrations of the РАН and nitroarenes. This research has involved kinetic and product studies of their atmospherically important gas-phase reactions,. analytical methods development and field studies t

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Mutagenesis Induced by a Single Acetylaminofluorene Adduct Within the NarI Site is Position Dependenne residues. It has been shown to mainly induce frameshift mutations in the bacteria E.Coli. These mutations occur within specific DNA sequences, the so-called mutation hot-spots. Among these, the NarI sequence (GGCGCC) is especially susceptible to -2 frameshift mutations (GGCGCC -->GGCC). Due to th

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