Titlebook: Nitrates and Nitrate Tolerance in Angina Pectoris; M. Kaltenbach,G. Kober Conference proceedings 1983 Dr. Dietrich Steinkopff Verlag, GmbH

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Tolerance from the Pharmacokinetic and Pharmacodynamic Viewpointsensitize a target organ; antagonists are not able to do this. For this reason it is probable that stimulation and desensitization properties of agonists are very closely correlated with one another. I should like to present the general problem of tolerance and its development and to point out the co

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Evaluation of Cross-Tolerance Between Long-Term Oral Isosorbide Dinitrate and Sublingual Nitroglycerrance to sublingually administered nitroglycerin by orally administered ISDN has assumed greater importance in view of the increased application of this agent in patients with ischemic heart disease in recent years. Therefere, we conducted a study to assess the effects of long-term oral administrati

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