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Titlebook: Nitrates and Nitrate Tolerance in Angina Pectoris; M. Kaltenbach,G. Kober Conference proceedings 1983 Dr. Dietrich Steinkopff Verlag, GmbH

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发表于 2025-3-21 18:12:49 | 显示全部楼层 |阅读模式
书目名称Nitrates and Nitrate Tolerance in Angina Pectoris
编辑M. Kaltenbach,G. Kober
视频video
图书封面Titlebook: Nitrates and Nitrate Tolerance in Angina Pectoris;  M. Kaltenbach,G. Kober Conference proceedings 1983 Dr. Dietrich Steinkopff Verlag, GmbH
出版日期Conference proceedings 1983
关键词angina pectoris; cardiology; drugs; heart; heart failure; hemodynamics
版次1
doihttps://doi.org/10.1007/978-3-642-85323-4
isbn_softcover978-3-642-85325-8
isbn_ebook978-3-642-85323-4
copyrightDr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1983
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发表于 2025-3-21 21:03:12 | 显示全部楼层
Hemodynamic and Ventricular Dynamic Investigations of Nitrate Tolerancetolerance exists with regard to a particular single effect of the drug or for the therapeutically desirable overall effect. Self-tolerance is the condition whereby a reduction in efficacy develops for the same substance, whereas cross-tolerance is when another similarly acting substance is ineffective.
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Long-Term Isosorbide Dinitrate Therapy for Pulmonary Hypertension in Patients with Chronic Obstructiapers confirmed the salutary effect of ISDN on pulmonary artery pressure (4, 8–10, 12, 14). It was generally administered only for a brief period. Both observed no favorable effect in long-term therapy.
发表于 2025-3-22 06:19:25 | 显示全部楼层
Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congesilure, while tolerance to nitrates as antianginal agents has been suggested (8–10). Furthermore, the venodilating effect of nitrates may become blunted with time (11). It is therefore extremely important to establish long-term hemodynamic efficacy of nitrates if they are to be important in the treatment of chronic congestive heart failure.
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Tolerance in Patients with Coronary Heart Disease Under Chronic Treatment with Isosorbide Dinitrate?, 20, 34). Definitions of tolerance, tachyphylaxis, and so on are given in Table 1. The main problem in chronic treatment with nitrates is whether tolerance occurs or not. We have carried out three studies and started a fourth with a view to providing an answer to this question.
发表于 2025-3-22 22:50:33 | 显示全部楼层
The Effect of Long-Acting Nitrates on Ambulatory ECG Changes in Patients with Angina Pectoris Treatefe of patients with angina. Although anginal frequency and glyceryl trinitrate consumption are important guides to therapy, they probably only represent the tip of the iceberg in terms of the number of episodes of transient myocardial ischemia these patients are experiencing (7).
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