Titlebook: Nitrates III; Cardiovascular Effec P. R. Lichtlen,H.-J. Engel,H. J. C. Swan (Director Conference proceedings 1981 Springer-Verlag Berlin He

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D. Brunner,J. Weisbord,N. Meshulam,S. Margulisw with the Massachusetts Teacher of the Year began with the question “Do you think kids are eating too much sugar?”. Her reply emphasized that she doesn’t allow candy because it makes children jumpy and hyperactive. This response is typical of many parents. Many families independently undertake diet

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Pharmacokinetics of Isosorbide Mononitrates in Human Subjectsundetectable levels [1]. Thus, isosorbide 5-mononitrate may make a major contribution to the “long-acting” antianginal activity of isosorbide dinitrate. This makes a study of the pharmacokinetics of isosorbide 5-mononitrate necessary.

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Effects of Acute and Chronic Administration of Isosorbide Dinitrate, Sustained-Release Form, in Patiaintained efficacy [1, 3, 9]. Apparently discrepant are the withdrawal symptoms, resulting from developed tolerance and observed in industrial workers chronically exposed to nitrates, the mechanism of which has been attributed to a resetting of vascular reactivity [7].

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Digital Pulse Plethysmography: a Sensitive Test of the Pharmacodynamics of Nitrates — Reproducibilittors of nitrate bioavailability. To study the feasibility of this method for application in pharmacologic investigations of nitrates we evaluated the reproducibility of measurements and dose-effect relationships with digital pulse plethysmography.

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t that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gain

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