Titlebook: Nitrates III; Cardiovascular Effec P. R. Lichtlen,H.-J. Engel,H. J. C. Swan (Director Conference proceedings 1981 Springer-Verlag Berlin He

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Plasma Concentrations and Hemodynamic Effects of Percutaneously Administered Nitroglycerin and Isoso healthy volunteers in whom we monitored the plasma concentrations and hemodynamic effects and assured the tolerability of nitroglycerin (NTG) and isosorbide dinitrate (ISDN) administered in the form of ointments.

Statins

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Pharmacokinetics — Pharmacodynamics and the Bioavailability of Organic Nitrate Drug Productsed directly from blood pressure, blood glucose, intraocular pressure, pupil size, heart rate, and clotting times, respectively. That such measures can be used for quantitative pharmacokinetic analysis and the computation of absolute biovailabilities has been demonstrated [5]. The growing sophisticat

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Tolerance to Circulatory and Clinical Effects of Nitratest was demonstrated in animals that the nitrates underwent extensive first-pass hepatic metabolism and that systemic drug levels were low [9]. However, demonstrations in man that oral isosorbide dinitrate (ISDN) prolonged hemodynamic effects [5] and improved exercise tolerance in angina pectoris [6]

PANG

Pharmacokinetics of Isosorbide Dinitrate in Human Subjects 7, 10] has facilitated study of the pharmacokinetics of this drug; the plasma levels obtainable after oral and sublingual doses of standard and sustained-release formulations and after topical applications of ointments are now well documented [1, 2, 8, 12].

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Pharmacokinetics of Isosorbide Mononitrates in Human Subjectsmononitrate and isosorbide 2-mononitrate (Fig. 1) [2], each of which is pharmacologically active [6]. In humans, about 10% of an oral dose of isosorbide dinitrate is excreted as both free and conjugated isosorbide 5-mononitrate, and about 1% is excreted as the 2-mononitrate [2]. After oral doses of

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Plasma Concentrations and Hemodynamic Effects of Percutaneously Administered Nitroglycerin and Isoso healthy volunteers in whom we monitored the plasma concentrations and hemodynamic effects and assured the tolerability of nitroglycerin (NTG) and isosorbide dinitrate (ISDN) administered in the form of ointments.

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使长胖