Titlebook: Nicotinic Receptors; Robin A.J. Lester Book 2014 Springer Science+Business Media New York 2014 behavior.disease.molecular structure.subtyp

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Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit, cancer, has been defined and redefined. For example, recent reports provide increasing evidence for α7’s involvement in the pathogenesis of Alzheimer’s disease, suggesting that further work is warranted to understand the roles of the α7 subunit normally and in pathophysiology.

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Role of Central Serotonin Receptors in Nicotine Addiction, the novel pharmacological approaches using 5-HT agents for the treatment of nicotine dependence. Compelling evidence shows that 5-HT. receptor agonists may be possible therapeutic targets for smoking cessation, although further investigation is required.

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Neuronal Nicotinic Acetylcholine Receptors in Reward and Addiction,t drug reward sensitivity, whereas with other drugs of abuse such as the psychostimulants and opioids, nAChRs play a more indirect, modulatory role on drug reward. In this chapter, the expression and function of nAChRs in the reinforcing/rewarding properties of drugs of abuse are explored.

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,Genetic Contributions of the α5 Nicotinic Receptor Subunit to Smoking Behavior,t and pharmacologic treatment so that those at highest genetic risk for failed smoking cessation respond most favorably to pharmacologic treatment to aid cessation. Hopefully this knowledge will improve smoking cessation efforts and reduce the health burdens associated with cigarette smoking.

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Smoking-Related Genes and Functional Consequences, duration of nicotine use, and yet another set is linked with severity of nicotine dependence. Associated “risky” genes comprise genes encoding for nicotinic acetylcholine receptor (nAChR) subunits, but also include genes like the bitter taste receptor. Still others have been associated with initiat

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Nicotinic Acetylcholine Receptors Along the Habenulo-Interpeduncular Pathway: Roles in Nicotine Wit the Hb-IPN pathway is one of the brain regions with the highest density of nAChRs, including both heteromeric (e.g., α3β4 and α4β2) and homomeric (i.e., α7) receptors. As nAChR subtypes that subserve multiple aspects of affective and reinforcement behaviors are expressed along this pathway, it is o

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Richard Martindale B.S.,Robin A. J. Lester Ph.D.al procedures as well as application of geostatistics are also reviewed. It reveals that water quality index is very effective technique to determine the suitability of water but it is limited to drinking water quality only. Moreover, the conventional indices evaluating the suitability of water for