Titlebook: Nicotinic Acetylcholine Receptor Technologies; Ming D. Li Book 2016 Springer Science+Business Media New York 2016 nAChR subunits.nicotinic

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,α7-Nicotinic Acetylcholine Receptors and β-Amyloid Peptides in Alzheimer’s Disease,pathogenesis of AD. In the brains of AD patients, α7-nAChR binding sites are reduced as well as α7-nAChR protein levels. Aβ binds to α7-nAChRs and modulates their function. Co-localization of α7-nAChRs, Aβ and amyloid plaques also indicates that these receptors play a role in the pathogenesis of AD.

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Evolutionary Relationship of Nicotinic Acetylcholine Receptor Subunits in Both Vertebrate and Inverence, other α and non-α subunits evolved within each lineage independently, suggesting a convergence in the evolution of nAChR subunits. In the invertebrate lineage, this gene duplication event seems to have occurred not long before splitting between nematoda and insecta. Furthermore, we suggest tha

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0893-2336 that ensures successful results inthe laboratory... ..Authoritative and practical, .Nicotinic AcetylcholineReceptor Technologies. aims. .to ensure successful results in thefurther study of this vital field..978-1-4939-8133-5978-1-4939-3768-4Series ISSN 0893-2336 Series E-ISSN 1940-6045

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