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Titlebook: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins; Ulf Grawunder,Stefan Barth Book 2017 Springer International Publishing A

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发表于 2025-3-21 19:11:04 | 显示全部楼层 |阅读模式
书目名称Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
编辑Ulf Grawunder,Stefan Barth
视频video
概述Offers cutting-edge information on the development of antibody drug conjugates and recombinant immunotoxins.Explores related basic biological and chemical technologies and promotes new developments to
丛书名称Milestones in Drug Therapy
图书封面Titlebook: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins;  Ulf Grawunder,Stefan Barth Book 2017 Springer International Publishing A
描述.This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.. .The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology..
出版日期Book 2017
关键词Antibody based cancer therapy; Antibody drug conjugates (ADC); Immunotoxin development; Pyrrolobenzodia
版次1
doihttps://doi.org/10.1007/978-3-319-46877-8
isbn_softcover978-3-319-83609-6
isbn_ebook978-3-319-46877-8Series ISSN 2296-6056 Series E-ISSN 2296-6064
issn_series 2296-6056
copyrightSpringer International Publishing AG 2017
The information of publication is updating

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发表于 2025-3-21 21:05:01 | 显示全部楼层
Milestones in Drug Therapyhttp://image.papertrans.cn/n/image/666181.jpg
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https://doi.org/10.1007/978-3-319-46877-8Antibody based cancer therapy; Antibody drug conjugates (ADC); Immunotoxin development; Pyrrolobenzodia
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Chemical Assembly of Antibody-Drug Conjugates, over 60 are in clinical trials. Although many ADCs involve non-specific drug attachment via lysine and cysteine residues, the desire to produce homogeneous ADCs has led to the development of several site-specific chemical assembly strategies. The first site-specific ADCs are just beginning to enter
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Stable and Homogeneous Drug Conjugation by Sequential Bis-Alkylation at Disulphide Bonds Using Bis-ion in ADC development is that much effort and time is needed to fully optimise the combination of antibody, linker and drug. New linker strategies are required to ensure that more homogeneous and stable ADCs can be produced with more predictable in vivo behaviour without the need for extensive re-o
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