Titlebook: New Therapeutic Targets in Rheumatoid Arthritis; Paul-Peter Tak Book 2009 Birkhäuser Basel 2009 Arthritis.Chemokine.Drug Target.Interleuki

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冷淡周边

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Interleukin-15, adaptive immune system. It binds to a heterotrimeric receptor consisting of the common γ-chain receptor, IL-15/IL-2 receptor β-chain and unique IL-15 receptor α-chain. IL-15 is expressed at the mRNA level in a variety of cell lineages and is expressed as protein as part of the rapid early inflammat

Leaven

IL-17 and Th17 cells, key players in arthritis,rged as the best-studied situation to justify the selection of IL-17 as a therapeutic target. By interacting with other proinflammatory cytokines, IL-17 was found to induce bone and cartilage destruction. In 2006, the precise cell source of IL-17 was identified in the mouse. These cells were named T

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招募

Perspectives in targeted therapy,lity of animal models for development of targeted therapies, clinical trial design, pharmacodynamics, immunobiology and key pathogenic elements of disease. Studies of chimeric anti-CD4 monoclonal antibodies in RA demonstrated the need for pre-clinical studies to more closely approximate the human th