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Titlebook: New Frontiers in Lifestyle-Related Diseases; Akira Miyazaki (Professor and Chairman),Michio Ima Conference proceedings 2008 Springer-Verla

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Neuronal Mechanisms of Feeding Regulation by Peptidesses. Feeding is regulated by complex interactions between orexigenic substances and anorectic substances, which are produced in the central nervous system and peripheral organs. Information about satiety or hunger is transmitted humorally and neurogenically to the brain, where it is integrated with
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Functional Analysis of GALP in Feeding Regulationhypothalamic arcuate nucleus (ARC) of the central nervous system, plays an important role in the regulation of feeding. GALP-containing neurons make an appetite-regulating neuronal circuit with other peptide-containing neurons involved in this process. While centrally administered GALP is known to s
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Atherogenic Lipoproteins in Type 2 Diabetes with Nephropathy when diabetic nephropathy is developed. The pathogenesis of CVD in diabetes is multifactorial, but dyslipidemia is thought to be a powerful risk factor for CVD. Although lipid metabolism has been extensively investigated in diabetes, little information is available concerning the influence of nephr
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Regulatory mechanisms for cytosolic prostaglandin E synthase, cPGES/p23etic pathway. Of interest, it is identical to the co-chaperone p23 that binds to heat shock protein 90 (Hsp90). Association of cPGES/p23 and Hsp90 resulted in a remarkable increase in PGES activity .. Next, we found that cPGES/p23 underwent serine phosphorylation, which was accelerated transiently a
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